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VOLUME 12, 2011  Issue Number 12 , 3221-3228
DownLoad : 3221-28 c11.8 Budda.pdf
RESEARCH COMMUNICATION
Suppressive Effects of Moringa oleifera Lam Pod Against
Mouse Colon Carcinogenesis Induced by Azoxymethane and
Dextran Sodium Sulfate
Sirintip Budda et al
Abstract
Moringa oleifera Lam (horseradish tree; tender pod or fruits) is a major ingredient in Thai cuisine and
has some medicinal properties. Previous studies have shown potentially antioxidant, antitumor promoter,
anticlastogen and anticarcinogen activities both in vitro and in vivo. The present study was conducted to investigate
chemopreventive effects on azoxymethane (AOM)-initiated and dextran sodium sulfate (DSS)-promoted colon
carcinogenesis in mice. Male ICR mice were divided into 8 groups: Group 1 served as a negative control; Group
2 received AOM/DSS as a positive control; Groups 3-5 were fed boiled freeze-dried M. oleifera (bMO) at 1.5%,
3.0% and 6.0%, respectively supplemented in basal diets for 5 weeks; Groups 6-8 were fed with bMO diets at
the designed doses above for 2 weeks prior to AOM, during and 1 week after DSS administration. At the end
of the study, colon samples were processed for histopathological examination. PCNA indices, iNOS and COX-2
expression were assessed by immunohistochemistry. The results demonstrated the incidences and multiplicities
of tumors in Groups 6-8 to be decreased when compared to Group 2 in a dose dependent manner, but this was
significant only in Group 8. The PCNA index was also significantly decreased in Group 8 whereas iNOS and
COX-2 protein expression were significantly decreased in Groups 7 and 8. The findings suggest that M. oleifera
Lam pod exerts suppressive effects in a colitis-related colon carcinogenesis model induced by AOM/DSS and
could serve as a chemopreventive agent.
Key Words: Moringa oleifera - chemoprevention - colon carcinogenesis - azoxymethane - dextran sodium sulfate
 
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