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VOLUME 10, 2009  Issue Number 5 , 887-890
DownLoad : 887 c Bakshi.pdf
RESEARCH COMMUNICATIONS
Crocin from Kashmiri Saffron (Crocus sativus) Induces in Vitro and in Vivo Xenograft Growth Inhibition of Dalton ¡¯ s Lymphoma (DLA) in Mice
Hamid Bakshi et al 887
Abstract
In this study we investigated in vitro and in vivo xenograft growth inhibition by crocin isolated from Kashmiri
saffron (Crocus sativus). It was found that crocin decreased cell viability in DLA cells, in a concentration- and
time-dependent manner. Significant increase in the lifespan of Dalton¡¯s lymphoma bearing animals was noted
by 37% and 44%, respectively. Furthermore, animals given treatment before induction of cancer showed 58%
increase in lifespan and there was 95.6% reduction of solid tumor in crocin treated animals on the 31st day after
tumor inoculation. Crocin also showed significant impact on hematological parameters, like the hemoglobin
count and numbers of lymphocytes. These findings support the conclusion that crocin from Crocus sativus has
significant anti-tumor activity.
Key Words: Crocus sativus - xenograft - crocin - Daltons lymphoma - alternate medicine
 
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