Interleukin-4-Receptor Alpha Gene Polymorphism and the Risk of Renal Cell Carcinoma in a South Indian Population
Shruthi Mohan et al
Abstract
The renal cell carcinoma (RCC) is a rare condition, accounting for only 3% of all adult malignancies although
constituting 90% of kidney cancers. The tumor is immunogenic and the host immune system may modulate the
clinical course of the disease. It has been reported that genetic polymorphisms in the interleukin-4-receptor
alpha gene are associated with risk and prognosis in RCCs. The present study is aimed at analyzing the presence
and significance of the interleukin-4-receptor alpha Ile50Val and Gln576Arg polymorphisms in a group of RCC
patients from South India. PCR-RFLP analysis was performed on genomic DNA isolated from blood samples
and the genotypes deduced. A significant association was found between the IL4 R alpha Val/Val genotype and
increased risk of RCC (OR: 3.45, CI: 1.15–10.38, P: 0.04). The Val/Val genotype was also found to be significantly
associated with increased risk in individuals below 54 years (OR: 5.79, CI: 1.33–25.07 P: 0.03) of age and in
females (OR: 7.47, CI: 1.4–39.84, P: 0.03). However, no significant association was observed with the Gln576Arg
polymorphism. Stratified analysis based on the genotypes and the stage of tumor revealed no significant
association. Thus, the present study indicates that IL4Ralpha could be a candidate gene for assessing the risk of
RCC.
Key Words: Renal cell carcinoma - IL4Ralpha gene polymorphism - South India
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