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VOLUME 14, 2013  Issue Number 7 , 4131-4134
DownLoad : 4131-4134 5.26 Xiaofeng Zhou.pdf
Allium Vegetables and Risk of Prostate Cancer: Evidence from 132,192 Subjects
Xiao-Feng Zhou et al
Objective: To evaluate the relationship between allium vegetable intake and risk of prostate cancer. Methods:
A systematic literature search up to May 2013 was carried out in PubMed, EMBASE, Scopus, Web of Science,
Cochrane register, and Chinese National Knowledge Infrastructure (CNKI) databases, and the references of
retrieved articles were also screened. The summary relative risks with 95% confidence interval for the highest
versus the lowest intake of allium vegetables were calculated. Heterogeneity and publication bias were also
evaluated. Results: A total of nine epidemiological studies consisting of six case–control and three prospective
cohort studies were included. We found a significantly decreased risk of prostate cancer for intake of allium
vegetables (OR = 0.82, 95% CI 0.70, 0.97). Moreover, in the subgroup analysis stratified by allium vegetable types,
significant associations were observed for garlic (OR = 0.77, 95% CI 0.64–0.91) but not onions (OR = 0.84, 95%
CI 0.62–1.13). Conclusions: Allium vegetables, especially garlic intake, are related to decreased risk of prostate
cancer. Because of the limited number of studies, further well-designed prospective studies are warranted to
confirm the findings of our study.
Key Words: Allium vegetables - garlic - onions - meta-analysis - prostatic neoplasms
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